No One-liner Can Ever Be Optimal.

Each Of The Major Sciences Has Contributed An Essential Ingredient In Our Long Retreat From An Initial Belief In Our Own Cosmic Importance. Astronomy Defined Our Home As A Small Planet Tucked Away In One Corner Of An Average Galaxy Among Millions; Biology Took Away Our Status As Paragons Created In The Image Of God; Geology Gave Us The Immensity Of Time And Taught Us How Little Of It Our Own Species Has Occupied.

[t]ruly Grand And Powerful Theories [...] Do Not And Cannot Rest Upon Single Observations. Evolution Is An Inference From Thousands Of Independent Sources, The Only Conceptual Structure That Can Make Unified Sense Of All This Disparate Information. The Failure Of A Particular Claim Usually Records A Local Error, Not The Bankruptcy Of A Central Theory. [...] If I Mistakenly Identify Your Father's Brother As Your Own Dad, You Don't Become Genealogically Rootless And Created De Novo. You Still Have A Father; We Just Haven't Located Him Properly.

You Put Three Facts Together - That All Organisms Produce More Offspring That Can Survive, That There's Variation Among Organisms, And That At Least Some Of That Variation Is Inherited - And The Syllogistic Inference Is Natural Selection.

Life Shows No Trend To Complexity In The Usual Sense-only An Asymmetrical Expansion Of Diversity Around A Starting Point Constrained To Be Simple.

No More Harmful Nonsense Exists Than [the] Common Supposition That Deepest Insight Into Great Questions About The Meaning Of Life Or The Structure Of Reality Emerges Most Readily When A Free, Undisciplined, And Uncluttered (read, Rather, Ignorant And Uneducated) Mind Soars Above Mere Earthly Knowledge And Concern.