It Has Yet To Be Shown By

It Has Not Escaped Our Notice That The Specific Pairing We Have Postulated Immediately Suggests A Possible Copying Mechanism For The Genetic Material.

Do Codons Overlap? In Other Words, As We Read Along The Genetic Message Do We Find A Base Which Is A Member Of Two Or More Codons? It Now Seems Fairly Certain That Codons Do Not Overlap.

Again The Message To Experimentalists Is: Be Sensible But Don't Be Impressed Too Much By Negative Arguments. If At All Possible, Try It And See What Turns Up. Theorists Almost Always Dislike This Sort Of Approach.

For Simplicity One Can Think Of The + Class As Having One Extra Base At Some Point Or Other In The Genetic Message And The - Class As Having One Too Few.

The Major Credit I Think Jim And I Deserve ... Is For Selecting The Right Problem And Sticking To It. It's True That By Blundering About We Stumbled On Gold, But The Fact Remains That We Were Looking For Gold. Both Of Us Had Decided, Quite Independently Of Each Other, That The Central Problem In Molecular Biology Was The Chemical Structure Of The Gene. ... We Could Not See What The Answer Was, But We Considered It So Important That We Were Determined To Think About It Long And Hard, From Any Relevant Point Of View.